Solar insolation in springtime influences age of onset of bipolar I disorder
2 ChronoRecord Association Inc. [Fullerton, USA]
3 Dalhousie University [Halifax]
4 Soviet Psychoneurological Hospital [Urai, Russia]
5 NORMENT - Norwegian Centre for Mental Disorders Research [Oslo]
6 University of Athens Medical School [Athens]
7 UniCa - Università degli Studi di Cagliari = University of Cagliari = Université de Cagliari
8 Faculty of Medicine [Hacettepe University]
9 Faculty of Medicine [Cologne]
10 NIMHANS - National Institute of Mental Health and Neurosciences [Bangalore]
11 Adelaide Medical School [Australia]
12 INPRF - National Institute of Psychiatry Ramón de la Fuente Muñiz [Mexico City]
13 VariaPsy - U1144 - Variabilité de réponse aux Psychotropes
14 BGU - Ben-Gurion University of the Negev
15 Deakin University [Melbourne Burwood]
16 University of Melbourne
17 Hacettepe University = Hacettepe Üniversitesi
18 Butabika Hospital [Kampala, Uganda]
19 UNISI - Università degli Studi di Siena = University of Siena
20 Mood Disorders Clinic, Dr. Jose Horwitz Psychiatric Institute,
21 Castle Peak Hospital [Hong Kong]
22 IMPACT - Centre for Innovation in Mental and Physical Health and Clinical Treatment [Geelong Victoria, Australia]
23 Aristotle University of Thessaloniki
24 Mayo Clinic [Rochester]
25 UPV / EHU - Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne]
26 [Northwestern University Medical School] - Feinberg School of Medicine [Northwestern University, Evanston]
27 MDCO - Mood Disorders Center of Ottawa
28 Kobe University
29 Tokyo Metropolitan Matsuzawa Hospital [Tokyo, Japan]
30 IMRB - Institut Mondor de Recherche Biomédicale
31 Perception et Mémoire / Perception and Memory
32 National Institute for Health and Welfare [Helsinki]
33 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
34 Tartu University Hospital
35 UFRGS - Universidade Federal do Rio Grande do Sul [Porto Alegre – Brasil] = Federal University of Rio Grande do Sul [Porto Alegre – Brazil]
36 Institute of Neuroscience and Physiology [Göteborg]
37 PUMS - Poznan University of Medical Sciences [Poland]
38 BIPOLAR Zentrum Wiener Neustadt [Wiener Neustadt, Austria]
39 Khanty-Mansiysk Clinical Psychoneurological Hospital [Khanty-Mansiysk, Russia]
40 Aarhus University Hospital
41 FMUSP - Universidade de São Paulo Medical School
42 Karolinska Institutet = Karolinska Institute [Stockholm]
43 AAU - Aalborg University
44 Universidad de Antoquia
45 University of Calgary
46 UMASS - University of Massachusetts Medical School [Worcester]
47 Institute of Mental Health [Singapore]
48 Michigan State University [Traverse City]
49 Department of Psychiatry [St. Olav's hospital, Trondheim]
50 NTNU - Norwegian University of Science and Technology [Trondheim]
51 UC San Diego - University of California [San Diego]
52 ABC - Asha Bipolar Clinic [Hyderabad, Telangana, India]
53 UTM - Tunis El Manar University [University of Tunis El Manar] [Tunisia] = Université de Tunis El Manar [Tunisie] = جامعة تونس المنار (ar)
54 Faculté de Médecine de Tunis
55 Hospital Ángeles del Pedregal [Mexico City, Mexico]
56 Centro Lucio Bini [Cagliari, Italy]
57 UDP - Universidad Diego Portales [Santiago - Chili]
58 IDM - Institute of Infectious Disease and Molecular Medicine
59 Stanford University
60 Goethe University Frankfurt = Goethe-Universität Frankfurt am Main
61 UMKC - University of Missouri [Kansas City]
62 UFBA - Universidade Federal da Bahia = Federal University of Bahia
63 University of Cape Town
64 Institute of Neuroscience Foundation Favaloro
65 Faculty of Medicine, University of Malaya [Kuala Lumpur, Malaisie]
66 TMIMS - Tokyo Metropolitan Institute of Medical Science
67 McLean Hospital [Belmont, Ma.]
68 UB - Universitat de Barcelona
69 Universitätsklinikum Frankfurt
70 CONACYT - Consejo Nacional de Ciencia y Tecnología [Mexico]
71 Chapman University
72 Semel Institute for Neuroscience and Human Behavior [Los Angeles, Ca]
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- PersonId : 757741
- IdHAL : bruno-etain
- ORCID : 0000-0002-5377-1488
- IdRef : 074181106
- Fonction : Auteur
- Fonction : Auteur
- Fonction : Auteur
- Fonction : Auteur
- PersonId : 785945
- ORCID : 0000-0003-1673-8248
Résumé
OBJECTIVE: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. METHOD: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. RESULTS: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). CONCLUSION: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.
