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Journal Articles Science Year : 2021

Antigenic evolution of dengue viruses over 20 years

Chris Chavez
Philippe Buchy
Veasna Duong
Philippe Dussart
Derek J. Smith
Richard Jarman


Infection with one of dengue viruses 1 to 4 (DENV1-4) induces protective antibodies against homotypic infection. However, a notable feature of dengue viruses is the ability to use preexisting heterotypic antibodies to infect Fcγ receptor–bearing immune cells, leading to higher viral load and immunopathological events that augment disease. We tracked the antigenic dynamics of each DENV serotype by using 1944 sequenced isolates from Bangkok, Thailand, between 1994 and 2014 (348 strains), in comparison with regional and global DENV antigenic diversity (64 strains). Over the course of 20 years, the Thailand DENV serotypes gradually evolved away from one another. However, for brief periods, the serotypes increased in similarity, with corresponding changes in epidemic magnitude. Antigenic evolution within a genotype involved a trade-off between two types of antigenic change (within-serotype and between-serotype), whereas genotype replacement resulted in antigenic change away from all serotypes. These findings provide insights into theorized dynamics in antigenic evolution.

Dates and versions

pasteur-03576364 , version 1 (16-02-2022)



Leah C. Katzelnick, Ana Coello Escoto, Angkana T. Huang, Bernardo Garcia-Carreras, Nayeem Chowdhury, et al.. Antigenic evolution of dengue viruses over 20 years. Science, 2021, 374 (6570), pp.999-1004. ⟨10.1126/science.abk0058⟩. ⟨pasteur-03576364⟩
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